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This practice guide from the Institute of Education Sciences (IES) provides an overview of effective classroom and intervention practices for the adolescent learner (Grades 4–12). It includes five recommendations based on research findings, suggestions for implementing those recommendations in the classroom, and strategies to address possible roadblocks or challenges. Developed as a resource for educators who directly interact with students such as classroom teachers, instructional coaches, school counselors and principals, it addresses the need to first improve reading comprehension skills to promote deeper understanding of content-area instruction. The first three recommendations focus on instructional strategies for content-area classes, the fourth references approaches for improving motivation and engagement for adolescent learners, and the fifth specifically targets struggling readers. Levels of evidence based on the IES Levels of Evidence for Practice Guides are provided for each recommendation.